Given all the problems with past inter-breeding you would have thought the Spanish royal family would have learned their lesson and avoided anymore Habsburg unions. Instead, the Spanish Borbons astonishingly followed the previous dynasty's policy of uncle-niece unions and double first cousins. Alfonso XIII was probably lucky to have avoided the fate of Carlos II!
And it was probably lucky that Francisco de Asis, the double first cousin of his wife Isabel II, was presumably not the biological father of his wife's children...
That seems like an understatement given that Isabel II and Francisco de Asis were both products of uncle-niece marriages as well as being double first cousins.
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