She was born in 1669 and was presumptive heiress to the trone until 1689.
There were several engagement negotiations in order for her to get marry.
All of them previewed the groom needed to settle in Portugal, therefore they all failed.
She got the nickname "A sempre-noiva" the Always Engaged.
The further a marriage cobtract went ahead was to her first cousin Victor-Amadeus II, duke of Savoy - their mothers being sisters, but V-A was not keen of leaving his duchy and the marriage contract was never duly signed.
Eventually, her mother died and her father re-married to Maria Sophia of Neuburg, daughter of the Palatine Elector and father several male sons, including the future D.Jo„o V in 1689.
Poor Isabel Luisa died of smallpox, still unmarried, the following year.
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