As Bjarne pointed out, it's fortunate that Francisco de Asis was probably not the biological father of their son and heir or a grotesque re-incarnation of Carlos II might once again have been seen stalking the corridors of El Escorial.
They started out all right. Felipe V married his second cousin (his brother Louis married her sister Marie Adelaide) and his second wife was not a close relative either.
His son did not marry very close relatives either but after the dynasty split in 3 reigning branches that were all marrying into the Austrian Habsburgs it did get worse.
It always amazed me that the Spanish Bourbons kept up the same rate of interbreeding as their Habsburg predecessors. Either they were ignorant of the causes of these traits or the class structure and importance of marrying equally was more important.
Even if not so exaggerated, it was also evident in Alfonso XIII, whose mother was a Habsburg, the daughter of two Habsburgs.
Given all the problems with past inter-breeding you would have thought the Spanish royal family would have learned their lesson and avoided anymore Habsburg unions. Instead, the Spanish Borbons astonishingly followed the previous dynasty's policy of uncle-niece unions and double first cousins. Alfonso XIII was probably lucky to have avoided the fate of Carlos II!
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