1609 Three Blind Mice was published in London. It is believed to be the earliest printed secular song

My goodness this is old. In grade school, in music, we learned to sing this as a round. It's a gruesome song, if you think about it.

1768 The Empress of Russia was inoculated with a new smallpox vaccine to set an example for her subjects

Good for her. I wonder if the peons had access to it as well as the upper crust.