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Cytoxan Treatment and Nephrotic Syndrome Posted by RalucaMac on September 6, 2007, 6:02 pm 12.177.96.141 Hi, My son is 3 1/2 and was diagnosed with Nephrotic Syndrome Minimal Change Disease last Sept 2006, he's been on 2 steroid treatments - 3 months steroids, 2 1/2 months off, then 4 1/2 months on steroids and now he is in relapse again after 2 1/2 months. Doctor is talking about the 8 weeks Cytoxan treatment. I am reading all side effects and I am so concerned. I do not know what to do. Did any of you have seen the side effects of this medication on your children? It's so hard to decide which direction to go not knowing how your child will respond to certain medication. How long before they decided to put your child on Cytoxan? How many steroid treatments and for how long? Any information on this from anyone would be so much appreciated. Anyone considered alternative medicine? Thank you all. Like everyone here, a very concerned parent, Raluca  Post a Response

Re: Cytoxan Treatment and Nephrotic Syndrome Posted by lilsea on October 6, 2007, 7:41 pm, in reply to "Cytoxan Treatment and Nephrotic Syndrome" 70.111.239.82 My 5 year old daughter was diagnosed with nephrotic syndrome this past July. We did 7 weeks of prednisone (at 6 weeks we added cytoxan) and she had no response. She hasn't had any side effects from the cytoxan (she's been on it for 2 weeks now), but I need to keep her away from people that are sick, have the sniffles, etc. My dr said that children normally respond to the steroids by 6 weeks, if not than they are steroid resistant. Those children are harder to treat because they need to use more aggressive meds and chances of relapse are higher than those that respond to the steroids. With the cytoxan, he said normally by 4 weeks on the meds, there is a response and urine proteins are down to 0. I wish you lots of great luck! --Previous Message-- : Hi, : : My son is 3 1/2 and was diagnosed with : Nephrotic Syndrome Minimal Change Disease : last Sept 2006, he's been on 2 steroid : treatments - 3 months steroids, 2 1/2 months : off, then 4 1/2 months on steroids and now : he is in relapse again after 2 1/2 months. : Doctor is talking about the 8 weeks Cytoxan : treatment. I am reading all side effects and : I am so concerned. I do not know what to do. : : Did any of you have seen the side effects of : this medication on your children? It's so : hard to decide which direction to go not : knowing how your child will respond to : certain medication. : : How long before they decided to put your : child on Cytoxan? How many steroid : treatments and for how long? Any information : on this from anyone would be so much : appreciated. Anyone considered alternative : medicine? : : Thank you all. : : Like everyone here, a very concerned parent, : Raluca :  Post a Response

Re: Cytoxan Treatment and Nephrotic Syndrome Posted by s-nathan on December 17, 2007, 4:49 pm, in reply to "Re: Cytoxan Treatment and Nephrotic Syndrome" 40.0.40.10 My son - almost 8 - is presumed to have "minimal change disease." Medically speaking, he is "steroid-dependent" (when we try to taper him off, he relapses). He has been on coticosteroid for the past 14+ months. We tried Cytoxan for 10 weeks starting early Aug 2007; he still relapsed about 3 weeks ago. Apparently, some kids are able to take breaks between steroid courses - before the relapse strikes. If such relapses WITH breaks happen frequently, those kids are termed "frequent relapsers" but NOT "steroid-dependent" I have read some of literature at www.pubmed.org Based on my reading, kids - in general - who are "frequent relapsers" tend to benefit from a course of "cytoxan" therapy. (I am just sharing what I read...not offering medical advice)  Post a Response

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