You are right. The illness ruined the royal marriage. After the PoA's birthday and the diagnosis, the couple was never the same. The King was aware that it was not her wife's fault, but he said he could not avoid blaming her for bringing the illness to his family.
No idea about Ena and Alix. I do not know even if they had any kind of relationship. We know about letters between Queen VE and Queen Mary, for example, but I have never read letters between the Queen of Spain and the Tsarina.
BTW, one of Queen VE descendants, Alessandro Lequio, grandson of Infanta Beatriz, has recently found out that he has a mild form of haemophilia. So, it seems Infanta Beatriz inherited the gene.
: I have just read Robert Service's excellent
: book "The Last of the Tsars",
: which describes in detail the end of the
: Romanov rule in Russia. It was known at the
: time that haemophilia was a genetic disorder
: and was present in some descendants of Queen
: Victoria. The fact that Nicholas's heir,
: Alexis, had inherited the disease was only
: known to the boy's parents and doctors,
: although some other members of the family
: and courtiers had an idea Alexis had this
: I understand that Queen Victoria Eugenie
: also carried the gene for the disease and
: that her and Alphonso XIII's eldest son,
: Alphonso, and their youngest son, Gonzalo,
: had the illness. Was this known to the
: public in Spain at the time? Do we think
: that Queen Ena and her cousin the Tsarina
: knew about the illness in each other's
: children? I know that the Tsar, for all his
: faults, was a loving husband and never
: blamed the Tsarina for the illness. I have
: heard King Alphonso was less understanding.
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